22,691 research outputs found

    On the Bayesian analysis of species sampling mixture models for density estimation

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    The mixture of normals model has been extensively applied to density estimation problems. This paper proposes an alternative parameterisation that naturally leads to new forms of prior distribution. The parameters can be interpreted as the location, scale and smoothness of the density. Priors on these parameters are often easier to specify. Alternatively, improper and default choices lead to automatic Bayesian density estimation. The ideas are extended to multivariate density estimation

    Nimbus Telemetry

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    Nimbus satellite - pulse-code-modulated telemetry subsyte

    Domain interactions within Fzo1 oligomers are essential for mitochondrial fusion

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    Mitofusins are conserved GTPases essential for the fusion of mitochondria. These mitochondrial outer membrane proteins contain a GTPase domain and two or three regions with hydrophobic heptad repeats, but little is known about how these domains interact to mediate mitochondrial fusion. To address this issue, we have analyzed the yeast mitofusin Fzo1p and find that mutation of any of the three heptad repeat regions (HRN, HR1, and HR2) leads to a null allele. Specific pairs of null alleles show robust complementation, indicating that functional domains need not exist on the same molecule. Biochemical analysis indicates that this complementation is due to Fzo1p oligomerization mediated by multiple domain interactions. Moreover, we find that two non-overlapping protein fragments, one consisting of HRN/GTPase and the other consisting of HR1/HR2, can form a complex that reconstitutes Fzo1p fusion activity. Each of the null alleles disrupts the interaction of these two fragments, suggesting that we have identified a key interaction involving the GTPase domain and heptad repeats essential for fusion

    Two-fluid hydrodynamics of a Bose gas including damping from normal fluid transport coefficients

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    We extend our recent work on the two-fluid hydrodynamics of the condensate and non-condensate in a trapped Bose gas by including the dissipation associated with viscosity and thermal conduction. For purposes of illustration, we consider the hydrodynamic modes in the case of a uniform Bose gas. A finite thermal conductivity and shear viscosity give rise to a damping of the first and second sound modes in addition to that found previously due to the lack of diffusive equilibrium between the condensate and non-condensate. The relaxational mode associated with this equilibration process is strongly coupled to thermal fluctuations and reduces to the usual thermal diffusion mode above the Bose-Einstein transition. In contrast to the standard Landau two-fluid hydrodynamics, we predict a damped mode centered at zero frequency, in addition to the usual second sound doublet.Comment: 18 pages, revtex, 4 postscript figures, Submitted to the Canadian Journal of Physics for the Boris Stoicheff Festschrift issu
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